Apoptosis as a therapeutic paradigm in inflammatory bowel diseases
| Journal | Volume 69 - 2006 |
| Issue | Fasc.4 - Symposium |
| Author(s) | Marleen I. Verstege, Anje A. te Velde, Daan W. Hommes |
| Full article |
 VIEW FREE PDF |
| (1) Centre for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands ; (2) Dept of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands. |
|
Evidence is increasing that a defect in apoptosis is involved in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). CD seems to be the cause of an intrinsic defect in the apoptotic pathway of (autore- active) T cells, resulting in excessive T cell responses. In UC, an increased rate of apoptosis of epithelial cells is observed. In this review we will describe apoptotic mechanisms and their associa- tion to IBD. In addition, we will review how specific therapeutic approaches interact at different levels with the apoptotic pathway. (Acta gastroenterol. belg., 2006, 69, 406-412). |
|
© Acta Gastro-Enterologica Belgica. |
